Creatine is the most studied sports supplement in history. Its benefits extend far beyond the gym — including brain health and neuroprotection.
Muscle Strength & Power
The ISSN position stand reviewed 500+ studies confirming creatine monohydrate as the most effective ergogenic supplement for increasing high-intensity exercise capacity and lean body mass.
Kreider RB, et al. J Int Soc Sports Nutr. 2017;14:18.
Cognitive Function
A systematic review of 6 RCTs found creatine supplementation significantly improved short-term memory and reasoning, particularly under conditions of stress or sleep deprivation — common in early recovery.
Avgerinos KI, et al. Exp Gerontol. 2018;108:166-173.
Neuroprotection
Research demonstrates creatine's neuroprotective properties, supporting brain energy metabolism and potentially protecting against neurodegenerative processes accelerated by substance use.
Rawson ES, Venezia AC. Amino Acids. 2011;40(5):1349-1362.
Exercise Performance
A comprehensive review confirmed creatine supplementation increases lean mass, strength, and power output across all exercise modalities, with 5-10% improvements in high-intensity performance.
Cooper R, et al. J Int Soc Sports Nutr. 2012;9(1):33.
Depression & Brain Health
Emerging research links creatine to improved mental health outcomes. Brain creatine levels are depleted in depression, and supplementation may support mood stability during recovery.
Allen PJ. Neurosci Biobehav Rev. 2012;36(5):1442-1462.
